Abstract: The density-dependent modified Drucker-Prager Cap (DPC) constitutive model of Ti-6Al-4V powders for cold die compaction was established by uniaxial compression test, diametrical compression test (Brazilian disc experiment), and die compression test in this paper, the constitutive model was verified by the user subroutine USDFLD in secondary development based on finite element software ABAQUS. Considering the influence of device deformation on experimental data in compaction process, the experimental error was controlled by calibration experiment, and the more accurate modified DPC model was established. The results show that, the modified DPC model of Ti-6Al-4V powders for cold die compaction can be accurately used in the simulation analysis of Ti-6Al-4V powders compaction. In addition, the wall friction decreases gradually with the increase of the top punch pressure when the top punch pressure is lower than 50 MPa; while the wall friction tends to be stable with the increase of the top punch pressure, when the top punch pressure is higher than 50 MPa.