Abstract: Tungsten is a very important refractory metal in the fields of nuclear fusion demonstration reactor, spallation neutron source, and semiconductor. The expected properties of tungsten plates can be obtained by rolling and deforming. The DEFORM software was used to simulate the rolling of tungsten plates in large size in this paper, and the influence of rolling mode on damage factor (damage value) and strain was analyzed. The results show that, the serious damage area for one-way rolling is mainly distributed at the side edge of the billets, which is easy to produce cracks; the serious damage area for cross rolling is uniformly distributed around the billets. The strain curves of cross rolling in the rolling direction may reach a “maximum value” and then descend to a “minimum value”, and the difference of strain between the two maximum value is smaller in cross rolling than that in one-way rolling.