Abstract: 3D printing, also known as additive manufacturing (AM), is a technology that uses 3D design data to build physical parts by adding materials layer by layer. With the application of information technology and intelligent control to 3D printing technology, the 3D printing technology is becoming more and more mature and commercialized gradually. The rapid development of manufacturing technology often requires the rapid follow-up of design technology. Topology optimization method has become an important tool for the structural innovative design because it is independent of the initial configuration and the engineer experience and can obtain completely unexpected innovative configurations. Embedded technology is a device or system that is controlled by an internal computer and performs a special function. Compared with the general purpose computer systems, the embedded systems have the advantages in 3D printing, such as low power consumption, powerful functions, strong real-time performance, multi-task support, small space occupation, and high efficiency, and the specific applications can be customized according to the needs of flexible. The application of topology optimization design and embedded digital technology in 3D printing was summarized in this paper, the application cases of topology optimization and the mainstream software of topology optimization were introduced, the application advantages and cases of the embedded technology in 3D printing were analyzed, and the future topology optimization design and the application of embedded digital technology in 3D printing were prospected.