Abstract: The difference of cold isostatic pressing between Mo-47.5wt%Re alloy powder prepared by ball milling and plasma spheroidized was compared and analyzed. The compression parameters were fitted using the double natural logarithm equation of "Huang Peiyun". The results show that, when cold isostatic pressing was carried out in the mold with large Length-diameter ratio, the axial shrinkage of the compact was greater than that of the radial shrinkage after the ball grinding and plasma spheroidized molybdenum-rhenium alloy powder were pressed. Pressed billet of the plasma spheroidization alloy powder is complete and uncracked, its density change less along the axial direction, and the centre density is slightly lower than the density at both ends. While the billet pressd with ball milling alloy powder is broken like bamboo joint, its density varies greatly along the axial direction, and the centre density is significantly lower than the density at both ends. The relationship between pressing pressure and green density was analyzed by Huang Peiyun's "double logarithmic pressing theory". It shows that the m value of plasma spheroidization alloy powder is slightly higher than that of ball milling alloy powder, while its M value lower than that of ball milling alloy powder, which means the hardening tendency of plasma spheroidization alloy powder is greater, and it is easier to press than ball milling alloy powder.