Abstract: The dispersed distribution of oxides can refine grain size and improve the mechanical properties of molybdenum matrix. There have been many studies on doping La2O3 and ZrO2 in molybdenum. Adding 14% mass fraction of rhenium to molybdenum can significantly enhance the strength and plasticity of the material, and improve processing performance at room temperature. This article investigates the effects of oxide doping on powder properties, sintering density, and room temperature mechanical properties by adding La2O3 and ZrO2 to molybdenum rhenium alloys, and compares the different effects of the two oxides. Research has found that doping with oxides can significantly reduce powder particle size and refine grain size, while doping with ZrO2 results in the smallest grain size but lower density; Rolling deformation can improve hardness and strength, doping La2O3 can obtain higher strength but unchanged elongation, and doping ZrO2 can improve strength while reducing plasticity; The effect of doping ZrO2 on strength enhancement is greater than that of doping La2O3, while the effect on elongation is opposite.