Abstract: Ti-3Al-5Mo-4Cr-2Zr-1Fe (Ti-35421) was prepared using hot press sintering. In order to enhance the quality of titanium alloys prepared through this method, orthogonal experiments were conducted to investigate the effects of sintering temperature, sintering pressure, and holding time on the microstructure and mechanical properties of hot-pressed sintered Ti35421. The study aimed to determine the optimal sintering parameters. The results revealed that temperature and pressure play crucial roles in influencing the microstructure and mechanical properties of the sintered alloy. Increasing the temperature promotes alloy densification, resulting in higher density and hardness. However, elevated temperatures can also lead to grain growth, which reduces the compressive properties of the alloy. By using an appropriate temperature and higher pressure, the overall mechanical properties of Ti35421 can be significantly improved. The alloy exhibited the best compressive properties when sintered at a temperature of 900 °C, a pressure of 45 MPa, and a duration of 2 hours. Under these conditions, the alloy demonstrated a yield strength of 1248 MPa and a fracture strain of 23.03%.