Abstract: The W–5.0Re–0.5HfC alloys were prepared by powder metallurgy, and the effects of three sintering processes on the microstructure and room-temperature mechanical properties of the alloys were systematically investigated, including hydrogen, vacuum, and vacuum+hydrogen sintering. The results indicate that the vacuum+hydrogen sintered billets exhibit the optimal comprehensive performance, with the average grain size (32.6 μm) and density (17.75 g·cm⁻³) intermediate between those of the hydrogen sintered (49.2 μm, 18.42 g·cm⁻³) and vacuum sintered (12.4 μm, 16.60 g·cm⁻³) billets, along with the optimal forging process adaptability. After the high-temperature deformation treatment, the room-temperature tensile strength of the vacuum+hydrogen sintered specimens (1425.11 MPa) is slightly lower than that of the hydrogen sintered specimens (1513.20 MPa), but the elongation significantly increases to 16.2%. The higher strength of the hydrogen sintered samples is attributed to the predominant presence of nano-sized hafnium carbide (HfC) particles through the dispersion strengthening mechanism. In contrast, the vacuum+hydrogen sintered specimens contain the hafnium oxide (HfO₂) particles, tightly bonding to the matrix, effectively refining the grains, and coordinating the dislocation motion, which markedly improve the plastic deformation capability and result in the optimal balance between strength and ductility.